Time-course expression of Toll-like receptors 2 and 4 in inflammatory bowel disease and homeostatic effect of VIP.

@article{Gomariz2005TimecourseEO,
  title={Time-course expression of Toll-like receptors 2 and 4 in inflammatory bowel disease and homeostatic effect of VIP.},
  author={Rosa P Gomariz and Alicia Arranz and Catalina Abad and Marta Torroba and Carmen Mart{\'i}nez and Florencia Rosignoli and Mar{\'i}a L. Garc{\'i}a-G{\'o}mez and Javier Leceta and Yasmina Juarranz},
  journal={Journal of leukocyte biology},
  year={2005},
  volume={78 2},
  pages={491-502}
}
Toll-like receptor 2 (TLR2) and -4 mediate signals from a great variety of bacterial gut products, giving the host a panel of microbe-recognizing receptors. Under homeostatic conditions, TLRs act as protective receptors of the intestinal epithelium. When homeostasis is disrupted in diseases such as inflammatory bowel disease, TLR2 and -4 are deregulated. Our study demonstrates, by using a trinitrobenzene sulfonic acid-induced colitis model of Crohn's disease, the constitutive expression and the… CONTINUE READING