Time-course changes of nerve growth factor, corticotropin-releasing hormone, and nitric oxide synthase isoforms and their possible role in the development of inflammatory response in experimental allergic encephalomyelitis.

@article{Calz1997TimecourseCO,
  title={Time-course changes of nerve growth factor, corticotropin-releasing hormone, and nitric oxide synthase isoforms and their possible role in the development of inflammatory response in experimental allergic encephalomyelitis.},
  author={Laura Calz{\`a} and Luciana Giardino and Mario Pozza and Alessandra Micera and Luigi Aloe},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 7},
  pages={3368-73}
}
In this paper we report a time-course study of development of experimental allergic encephalomyelitis in Lewis rats, by monitoring neuroendocrine regulation of the hypothalamus-pituitary-adrenal axis through corticotropin-releasing hormone mRNA expression, inflammatory cellular infiltrate, macrophagic and neuronal nitric oxide synthase, nerve growth factor (NGF), and NGF p75 and trkA receptors in the brain and spinal cord. We analyzed animals during 20 days after immunization, a time interval… CONTINUE READING

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