Time course changes in [Ca2+]i, force, and protein content in hindlimb-suspended mouse soleus muscles.

@article{Ingalls2001TimeCC,
  title={Time course changes in [Ca2+]i, force, and protein content in hindlimb-suspended mouse soleus muscles.},
  author={Christopher Paul Ingalls and Joseph C. Wenke and Robert B Armstrong},
  journal={Aviation, space, and environmental medicine},
  year={2001},
  volume={72 5},
  pages={471-6}
}
BACKGROUND Exposure to reduced gravitational forces during spaceflight is associated with significant reductions in skeletal muscle mass and strength. The purpose of this study was to test the hypothesis that increases in resting cytosolic free calcium concentration ([Ca2+]i) would precede reductions in protein content and maximal isometric tetanic force (Po) in mouse soleus muscle after initiation of hindlimb suspension. METHODS Female ICR mice (n = 42) were hindlimb suspended for 1, 2, 3, 5… CONTINUE READING
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