Time course and voltage dependence of expressed HERG current compared with native ”rapid” delayed rectifier K current during the cardiac ventricular action potential

@article{Hancox1998TimeCA,
  title={Time course and voltage dependence of expressed HERG current compared with native ”rapid” delayed rectifier K current during the cardiac ventricular action potential},
  author={Jules C. Hancox and Allan J. Levi and Harry J. Witchel},
  journal={Pfl{\"u}gers Archiv},
  year={1998},
  volume={436},
  pages={843-853}
}
 It is widely believed that HERG (human ether-a-go-go-related gene) encodes the major subunit of the cardiac ”rapid” delayed rectifier K channel. The aims of the present study were threefold: (1) to record directly the time course and voltage dependence of expressed HERG current in a mammalian cell line, during an imposed ventricular action potential (AP); (2) to compare this with native rapid delayed rectifier current (I Kr) elicited by applying an AP command to isolated guinea-pig ventricular… CONTINUE READING