Time-course and regional analyses of the physiopathological changes induced after cerebral injection of an amyloid β fragment in rats.

@article{Zussy2011TimecourseAR,
  title={Time-course and regional analyses of the physiopathological changes induced after cerebral injection of an amyloid β fragment in rats.},
  author={Charleine Zussy and Anthony Brureau and Brice Delair and St{\'e}phane Marchal and Emeline Keller and Guy Ixart and Gaelle Naert and Johann Meunier and Nathalie Chevallier and Tangui Maurice and Laurent Givalois},
  journal={The American journal of pathology},
  year={2011},
  volume={179 1},
  pages={315-34}
}
Alzheimer's disease (AD) is a neurodegenerative pathology characterized by the presence of senile plaques and neurofibrillary tangles, accompanied by synaptic and neuronal loss. The major component of senile plaques is an amyloid β protein (Aβ) formed by pathological processing of the Aβ precursor protein. We assessed the time-course and regional effects of a single intracerebroventricular injection of aggregated Aβ fragment 25-35 (Aβ(25-35)) in rats. Using a combined biochemical, behavioral… CONTINUE READING
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