Time course and nature of brain atrophy in the MRL mouse model of central nervous system lupus.

@article{Sled2009TimeCA,
  title={Time course and nature of brain atrophy in the MRL mouse model of central nervous system lupus.},
  author={John G. Sled and Shoshana Spring and Matthijs C van Eede and Jason P. Lerch and Sangeeta Ullal and Boris {\vS}aki{\'c}},
  journal={Arthritis and rheumatism},
  year={2009},
  volume={60 6},
  pages={1764-74}
}
OBJECTIVE Similar to patients with systemic lupus erythematosus, autoimmune MRL/lpr mice spontaneously develop behavioral deficits and pathologic changes in the brain. Given that the disease-associated brain atrophy in this model is not well understood, the present study was undertaken to determine the time course of morphometric changes in major brain structures of autoimmune MRL/lpr mice. METHODS Computerized planimetry and high-resolution magnetic resonance imaging (MRI) were used to… CONTINUE READING