Time course and morphology of dopaminergic neuronal death caused by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

@article{JacksonLewis1995TimeCA,
  title={Time course and morphology of dopaminergic neuronal death caused by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.},
  author={Vernice R. Jackson-Lewis and Michael W. Jakowec and Robert E Burke and Serge E. Przedborski},
  journal={Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration},
  year={1995},
  volume={4 3},
  pages={257-69}
}
Mechanisms responsible for 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopamine (DA) neuronal death remain unknown and in mice it is even unclear whether neuronal death does occur. In vitro studies suggest that 1-methyl-4-phenylpyridinium ion (MPP+), the active metabolite of MPTP, kills neurons by apoptosis. Herein, we investigated whether MPTP induces DA neuronal death in vivo in mice and whether the mechanism is that of apoptosis. C57/bl Mice received different doses of MPTP… CONTINUE READING
Highly Influential
This paper has highly influenced a number of papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Connections & Topics

Mentioned Connections BETA
We found that MPTP induces neuronal destruction in the substantia nigra pars compacta ( SNpc ) and the ventral tegmental area ( VTA ) .
Substantia nigra structureIs location of anatomic structurePars Compacta
We found that MPTP induces neuronal destruction in the substantia nigra pars compacta ( SNpc ) and the ventral tegmental area ( VTA ) .
We found that MPTP induces neuronal destruction in the substantia nigra pars compacta ( SNpc ) and the ventral tegmental area ( VTA ) .
We found that MPTP induces neuronal destruction in the substantia nigra pars compacta ( SNpc ) and the ventral tegmental area ( VTA ) .
We found that MPTP induces neuronal destruction in the substantia nigra pars compacta ( SNpc ) and the ventral tegmental area ( VTA ) .
C57/bl Mice received different doses of MPTP administered in four intraperitoneal injections every 2 hours and were sacrificed at different time points for analyses of tyrosine hydroxylase ( TH ) immunohistochemistry , silver staining , and Nissl staining within the mesencephalon .
C57/bl Mice received different doses of MPTP administered in four intraperitoneal injections every 2 hours and were sacrificed at different time points for analyses of tyrosine hydroxylase ( TH ) immunohistochemistry , silver staining , and Nissl staining within the mesencephalon .
All Topics