Time course and manner of Purkinje neuron death following a single ethanol exposure on postnatal day 4 in the developing rat.

@article{Light2002TimeCA,
  title={Time course and manner of Purkinje neuron death following a single ethanol exposure on postnatal day 4 in the developing rat.},
  author={Kim Edward Light and Scott M. Belcher and Dwight R. Pierce},
  journal={Neuroscience},
  year={2002},
  volume={114 2},
  pages={327-37}
}
The present study was designed to evaluate the time course and manner of Purkinje cell death following a single ethanol dose delivered intragastrically on postnatal day (PN) 4 to rat pups. Analysis included immunolabeling of Purkinje cells with antibody specific for calbindin D28k and counting of Purkinje cells in each lobule of a mid-vermal slice. Terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling analysis and immunodetection for cleaved (activated) caspase-3 enzyme was used… CONTINUE READING
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