Time-course and dose-response study on the effects of chronic L-DOPA administration on striatal dopamine levels and dopamine transporter following MPTP toxicity.

@article{Fornai2000TimecourseAD,
  title={Time-course and dose-response study on the effects of chronic L-DOPA administration on striatal dopamine levels and dopamine transporter following MPTP toxicity.},
  author={Francesco Fornai and George Battaglia and Marco Gesi and Fillippo Sean Giorgi and Francesco Orzi and Ferdinando Nicoletti and Stefano Ruggieri},
  journal={Brain research},
  year={2000},
  volume={887 1},
  pages={110-7}
}
Despite a long-lasting therapeutic use of L-DOPA in Parkinson's disease, doubts still remain concerning the possibility that chronic L-DOPA might accelerate the progression of this movement disorder. To address this point, in the present study we examined the effects of chronic L-DOPA administration either in intact or MPTP-treated parkinsonian mice. We produced an intermediate striatal dopamine loss by administering a low dose of MPTP (30 mg/kg); then, we treated mice chronically, for… CONTINUE READING

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