Time controlled release of arabinofuranosylcytosine (Ara-C) from agarose hydrogels using layer-by-layer assembly: an in vitro study.

@article{Mehrotra2012TimeCR,
  title={Time controlled release of arabinofuranosylcytosine (Ara-C) from agarose hydrogels using layer-by-layer assembly: an in vitro study.},
  author={Sumit Mehrotra and Daniel A Lynam and Chun Liu and Dena Shahriari and Ilsoon Lee and Mark H Tuszynski and Jeffrey Steven Sakamoto and Christina Chan},
  journal={Journal of biomaterials science. Polymer edition},
  year={2012},
  volume={23 1-4},
  pages={
          439-63
        }
}
Experimentally induced axonal regeneration is compromised by glial scar formation arising from leptomeningeal fibroblasts cells in and around the hydrogel scaffold implanted for nerve repair. Strategies are needed to prevent such fibroblastic reactive cell layer formation for enhanced axonal regeneration. Here, we implement the technique of layer-by-layer assembled degradable, hydrogen bonded multilayers on agarose hydrogels to incorporate an anti-mitotic drug (1-β-D-arabinofuranosylcytosine… CONTINUE READING
BETA

Similar Papers

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-9 OF 9 CITATIONS