Time-based understanding of DLCO and DLNO

  title={Time-based understanding of DLCO and DLNO},
  author={M Kang and B. Sapoval},
  journal={Respiratory Physiology & Neurobiology},
Capture of CO and NO by blood requires molecules to travel by diffusion from alveolar gas to haemoglobin molecules inside RBCs and then to react. One can attach to these processes two times, a time for diffusion and a time for reaction. This reaction time is known from chemical kinetics and, therefore, constitutes a unique physical clock. This paper presents a time-based bottom-up theory that yields a simple expression for DLCO and DLNO that produces quantitative predictions which compare… CONTINUE READING


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