Time- and dose-related effects of estradiol and diethylstilbestrol on the morphology and function of the fetal rat testis in culture.

@article{Lassurgure2003TimeAD,
  title={Time- and dose-related effects of estradiol and diethylstilbestrol on the morphology and function of the fetal rat testis in culture.},
  author={Julie Lassurgu{\`e}re and Gabriel Livera and Ren{\'e} Habert and B. J{\'e}gou},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2003},
  volume={73 1},
  pages={
          160-9
        }
}
UNLABELLED The mechanisms underlying the action of estrogens in the fetal testis are still largely obscure. In particular, whether this action is direct or indirect remains largely unexplored. This study was aimed at investigating the effect of estradiol (E2) and diethylstilbestrol (DES) on the testis from 14.5-day-old rat fetuses in culture, at concentrations ranging from 4 x 10(-10) M (Kd of E2 for the estrogen receptors [ER]: 1-4 x 10(-10) M) to 4 x 10(-6) M (concentration previously shown… CONTINUE READING

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