Time and amplitude regulation of pulsatile insulin secretion by triggering and amplifying pathways in mouse islets.

@article{Ravier2002TimeAA,
  title={Time and amplitude regulation of pulsatile insulin secretion by triggering and amplifying pathways in mouse islets.},
  author={Magalie A. Ravier and J. -C. Henquin},
  journal={FEBS letters},
  year={2002},
  volume={530 1-3},
  pages={215-9}
}
Glucose-induced insulin secretion is pulsatile. We investigated how the triggering pathway (rise in beta-cell [Ca(2+)](i)) and amplifying pathway (greater Ca(2+) efficacy on exocytosis) influence this pulsatility. Repetitive [Ca(2+)](i) pulses were imposed by high K(+)+ diazoxide in single mouse islets. Insulin secretion (measured simultaneously) tightly followed [Ca(2+)](i) changes. Lengthening [Ca(2+)](i) pulses increased the duration but not the amplitude of insulin pulses. Increasing… CONTINUE READING

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