Time-Specific Effects of Spindle Positioning on Embryonic Progenitor Pool Composition and Adult Neural Stem Cell Seeding

@inproceedings{Falk2017TimeSpecificEO,
  title={Time-Specific Effects of Spindle Positioning on Embryonic Progenitor Pool Composition and Adult Neural Stem Cell Seeding},
  author={Stephan Falk and Stéphane Bugeon and Jovica Ninkovic and Gregor-Alexander Pilz and Maria Pia Postiglione and Harold Cremer and Juergen A. Knoblich and Magdalena G{\"o}tz},
  booktitle={Neuron},
  year={2017}
}
The developmental mechanisms regulating the number of adult neural stem cells (aNSCs) are largely unknown. Here we show that the cleavage plane orientation in murine embryonic radial glia cells (RGCs) regulates the number of aNSCs in the lateral ganglionic eminence (LGE). Randomizing spindle orientation in RGCs by overexpression of Insc or a dominant-negative form of Lgn (dnLgn) reduces the frequency of self-renewing asymmetric divisions while favoring symmetric divisions generating two SNPs… CONTINUE READING

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