Time-Lapse Retinal Ganglion Cell Dendritic Field Degeneration Imaged in Organotypic Retinal Explant Culture

@inproceedings{Johnson2016TimeLapseRG,
  title={Time-Lapse Retinal Ganglion Cell Dendritic Field Degeneration Imaged in Organotypic Retinal Explant Culture},
  author={Thomas V. Johnson and Ericka N. Oglesby and Matthew R. Steinhart and Elizabeth Cone-Kimball and Joan L. Jefferys and Harry A. Quigley},
  booktitle={Investigative ophthalmology & visual science},
  year={2016}
}
PURPOSE To develop an ex vivo organotypic retinal explant culture system suitable for multiple time-point imaging of retinal ganglion cell (RGC) dendritic arbors over a period of 1 week, and capable of detecting dendrite neuroprotection conferred by experimental treatments. METHODS Thy1-YFP mouse retinas were explanted and maintained in organotypic culture. Retinal ganglion cell dendritic arbors were imaged repeatedly using confocal laser scanning microscopy. Maximal projection z-stacks were… CONTINUE READING
1
Twitter Mention

Citations

Publications citing this paper.
SHOWING 1-10 OF 12 CITATIONS

Brain‐derived neurotrophic factor prevents dendritic retraction of adult mouse retinal ganglion cells

  • The European journal of neuroscience
  • 2016
VIEW 5 EXCERPTS
CITES BACKGROUND, RESULTS & METHODS
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 46 REFERENCES

The potential of stem cell research for the treatment of neuronal damage in glaucoma

MO Karl
  • Cell Tissue Res
  • 2013
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Differential progression of structural and functional alterations in distinct retinal ganglion cell types in a mouse model of glaucoma

L Della Santina, DM Inman, CB Lupien, PJ Horner, RO. Wong
  • J Neurosci. 2013;33:17444–17457
  • 2016