Time-Dependent Compensatory Responses to Chronic Neuroinflammation in Hippocampus and Brainstem: The Potential Role of Glutamate Neurotransmission

@inproceedings{Brothers2013TimeDependentCR,
  title={Time-Dependent Compensatory Responses to Chronic Neuroinflammation in Hippocampus and Brainstem: The Potential Role of Glutamate Neurotransmission},
  author={Holly M. Brothers and Isabelle Bardou and Sarah C Hopp and Yannick Marchalant and Roxanne M. Kaercher and Sarah M. Turner and Mollie R. Mitchem and Kristina A Kigerl and Gary L. Wenk},
  booktitle={Journal of Alzheimer's disease & Parkinsonism},
  year={2013}
}
Chronic neuroinflammation is characteristic of neurodegenerative diseases and is present during very early stages, yet significant pathology and behavioral deficits do not manifest until advanced age. We investigated the consequences of experimentally-induced chronic neuroinflammation within the hippocampus and brainstem of young (4 mo) F-344 rats. Lipopolysaccharide (LPS) was infused continuously into the IVth ventricle for 2, 4 or 8 weeks. The number of MHC II immunoreactive microglia in the… CONTINUE READING

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