Time, space and the vertebrate body axis.

  title={Time, space and the vertebrate body axis.},
  author={Antony J Durston},
  journal={Seminars in cell & developmental biology},
Anterior-posterior (A-P) patterning of the vertebrate main body axis regulated by timing. Anterior structures are specified early, posterior late. (1) Timing involves timed decision points as emphasised by the Wnt studies of Sokol and colleagues. It also involves complex timers, where large parts of the axis are patterned sequentially by a common upstream mechanism (articles by Durston et al., Mullins et al., Oates et al.,). (2) A gastrula BMP-anti BMP dependent time-space translation (TST… CONTINUE READING
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