Tim50 Is a Subunit of the TIM23 Complex that Links Protein Translocation across the Outer and Inner Mitochondrial Membranes

@article{Yamamoto2002Tim50IA,
  title={Tim50 Is a Subunit of the TIM23 Complex that Links Protein Translocation across the Outer and Inner Mitochondrial Membranes},
  author={Hayashi Yamamoto and Masatoshi Esaki and Takashi Kanamori and Yasushi Tamura and Shuh-ichi Nishikawa and Toshiya Endo},
  journal={Cell},
  year={2002},
  volume={111},
  pages={519-528}
}
Based on the results of site-specific photocrosslinking of translocation intermediates, we have identified Tim50, a component of the yeast TIM23 import machinery, which mediates translocation of presequence-containing proteins across the mitochondrial inner membrane. Tim50 is anchored to the inner mitochondrial membrane, exposing the C-terminal domain to the intermembrane space. Tim50 interacts with the N-terminal intermembrane space domain of Tim23. Functional defects of Tim50 either by… CONTINUE READING
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