Tim3 binding to galectin-9 stimulates antimicrobial immunity

  title={Tim3 binding to galectin-9 stimulates antimicrobial immunity},
  author={Pushpa Jayaraman and Isabel Sada-Ovalle and Sarah Beladi and Ana Carrizossa Anderson and Val{\'e}rie A Dardalhon and Chie Hotta and Vijay K Kuchroo and Samuel M Behar},
  booktitle={The Journal of experimental medicine},
T cell immunoglobulin and mucin domain 3 (Tim3) is a negative regulatory molecule that inhibits effector T(H)1-type responses. Such inhibitory signals prevent unintended tissue inflammation, but can be detrimental if they lead to premature T cell exhaustion. Although the role of Tim3 in autoimmunity has been extensively studied, whether Tim3 regulates antimicrobial immunity has not been explored. Here, we show that Tim3 expressed on T(H)1 cells interacts with its ligand, galectin-9 (Gal9… CONTINUE READING
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