Tim-3 protects decidual stromal cells from toll-like receptor-mediated apoptosis and inflammatory reactions and promotes Th2 bias at the maternal-fetal interface

@inproceedings{Wang2015Tim3PD,
  title={Tim-3 protects decidual stromal cells from toll-like receptor-mediated apoptosis and inflammatory reactions and promotes Th2 bias at the maternal-fetal interface},
  author={Songcun Wang and Chunmei Cao and Hailan Piao and Yanhong Li and Yu Ting Tao and Xiaoming Zhang and Di Zhang and Chan Sun and Rui Zhu and Yan Xiu Wang and MinMin Yuan and Dajin Li and Meirong Du},
  booktitle={Scientific reports},
  year={2015}
}
Toll-like receptors (TLRs) are important in mediating immune responses against various pathogens during pregnancy. However, uncontrolled TLR-triggered inflammation will endanger normal pregnancy, resulting in pregnancy loss. Therefore, maintenance of a moderate inflammatory response is crucial for successful pregnancy under conditions of infection. Here, we demonstrated significantly lowered expression of T-cell immunoglobulin and mucin domain 3 (Tim-3) in miscarried decidual stromal cells… CONTINUE READING
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