Tim-3 Expression on Tumor-Infiltrating PD-1+CD8+ T Cells Correlates with Poor Clinical Outcome in Renal Cell Carcinoma.

@article{Granier2017Tim3EO,
  title={Tim-3 Expression on Tumor-Infiltrating PD-1+CD8+ T Cells Correlates with Poor Clinical Outcome in Renal Cell Carcinoma.},
  author={Cl{\'e}mence Granier and Charles Dariane and Pierre Combe and Virginie Verkarre and Sa{\"i}k Urien and C{\'e}cile Badoual and Helene Roussel and Marion Mandavit and Patrice Ravel and Mathilde Sibony and L. Biard and Cam{\'e}lia Radulescu and Emeline Vinatier and Nadine Benhamouda and Michael Peyromaure and Stephane Oudard and Arnaud M{\'e}jean and M O Timsit and Alain Gey and Eric Tartour},
  journal={Cancer research},
  year={2017},
  volume={77 5},
  pages={1075-1082}
}
Inhibitory receptors expressed by T cells mediate tolerance to tumor antigens, with coexpression of these receptors exacerbating this dysfunctional state. Using the VectraR automated multiparametric immunofluorescence technique, we quantified intratumoral CD8+ T cells coexpressing the inhibitory receptors PD-1 and Tim-3 from patients with renal cell carcinoma (RCC). A second validation cohort measured the same parameters by cytometry. The percentage of tumor-infiltrating CD8+ T cells… CONTINUE READING