Tim-1 is induced on germinal centre B cells through B-cell receptor signalling but is not essential for the germinal centre response.

Abstract

T-cell immunoglobulin mucin-1 (Tim-1) has been proposed to be an important T-cell immunoregulatory molecule since its expression on activated T cells was discovered. To study the role of Tim-1 on T cells in vitro and in vivo we generated both Tim-1-deficient mice and several lines of Tim-1 transgenic mice with Tim-1 expression on either T cells, or B and T… (More)
DOI: 10.1111/j.1365-2567.2010.03276.x

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