Tilmicosin and tylosin have anti-inflammatory properties via modulation of COX-2 and iNOS gene expression and production of cytokines in LPS-induced macrophages and monocytes.

@article{Cao2006TilmicosinAT,
  title={Tilmicosin and tylosin have anti-inflammatory properties via modulation of COX-2 and iNOS gene expression and production of cytokines in LPS-induced macrophages and monocytes.},
  author={Xing-Yuan Cao and Mei Dong and Jian-zhong Shen and Bei-bei Wu and C M Wu and Xiang-dang Du and Zhihua Wang and Y Qi and Bing-Yu Li},
  journal={International journal of antimicrobial agents},
  year={2006},
  volume={27 5},
  pages={431-8}
}
Macrolides have been reported to modify the host immune and inflammatory responses both in vivo and in vitro. We examined the in vitro effect of the macrolides tilmicosin and tylosin, which are only used in the veterinary clinic, on the production of nitric oxide (NO), prostaglandin E(2) (PGE(2)) and cytokines by lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages and mouse peripheral blood mononuclear cells (PBMCs). Compared with 5 microg/mL, tilmicosin and tylosin concentrations of 10… CONTINUE READING
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