Tiliroside and gnaphaliin inhibit human low density lipoprotein oxidation.

  title={Tiliroside and gnaphaliin inhibit human low density lipoprotein oxidation.},
  author={Guillermo Schinella and Horacio A Tournier and Salvador M{\'a}{\~n}ez and Perla M de Buschiazzo and Mar{\'i}a Del Carmen Recio and Jos{\'e} P{\'e}rez R{\'i}os},
  volume={78 1},
Two flavonoids, gnaphaliin and tiliroside, isolated from Helichrysum italicum, were studied in vitro for their capacity to inhibit Cu(2+)-induced human low density lipoprotein (LDL) and diluted plasma oxidation. LDL oxidation was monitored by conjugated diene, thiobarbituric acid-reactive substances (TBARS) formation and electrophoretic mobility on agarose gel. Gnaphaliin and tiliroside increased the lag-phase for diene conjugate production in a dose-dependent manner. The reduction of TBARS… CONTINUE READING