Tiling resolution array CGH and high density expression profiling of urothelial carcinomas delineate genomic amplicons and candidate target genes specific for advanced tumors

@article{Heidenblad2007TilingRA,
  title={Tiling resolution array CGH and high density expression profiling of urothelial carcinomas delineate genomic amplicons and candidate target genes specific for advanced tumors},
  author={Markus Heidenblad and David Lindgren and Tord Jonson and Fredrik Liedberg and Srinivas Veerla and Gunilla Chebil and Sigurdur V Gudjonsson and {\AA}ke Borg and Wiking M{\aa}nsson and Mattias H{\"o}glund},
  journal={BMC Medical Genomics},
  year={2007},
  volume={1},
  pages={3 - 3}
}
Urothelial carcinoma (UC) is characterized by nonrandom chromosomal aberrations, varying from one or a few changes in early-stage and low-grade tumors, to highly rearranged karyotypes in muscle-invasive lesions. Recent array-CGH analyses have shed further light on the genomic changes underlying the neoplastic development of UC, and have facilitated the molecular delineation amplified and deleted regions to the level of specific candidate genes. In the present investigation we combine detailed… CONTINUE READING
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