Tiki Casts a Spell on Wnt

@article{Vincent2012TikiCA,
  title={Tiki Casts a Spell on Wnt},
  author={J. Oswald Vincent and Tony Magee},
  journal={Cell},
  year={2012},
  volume={149},
  pages={1426-1427}
}
Negative feedback is a widespread feature of signaling pathways. In an unexpected twist described in this issue, He and colleagues identify a membrane-tethered metalloprotease named Tiki that inhibits Wnt signaling by removing an essential eight-residue fragment from Wnt itself. 

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