Tigliane-type phorbols stimulate human melanocyte proliferation: potentially safer agents for melanocyte culture.


Previous studies have established that some phorbol compounds that are active in binding to protein kinase C (PKC) are also strong mitogens for human melanocytes in culture. Structure/activity studies on tigliane class phorbol compounds, which lack an oxygen at the 12 position, have shown that tumor-promoting activity can be diminished or abolished though… (More)


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