Tigliane-type diterpenoid glycosides from Euphorbia fischeriana.

  title={Tigliane-type diterpenoid glycosides from Euphorbia fischeriana.},
  author={Li-li Pan and Ping-Lei Fang and Xing-jie Zhang and Wei Ni and Lei Thor Li and Liu-meng Yang and Chang-xiang Chen and Yong-Tang Zheng and Chang-Tian Li and Xiao-Jiang Hao and Hai-Yang Liu},
  journal={Journal of natural products},
  volume={74 6},
Investigation of whole plants of Euphorbia fischeriana afforded three new tigliane-diterpenoid glycosides, fischerosides A-C (1-3), together with 11 known diterpenoids. Fischerosides A-C (1-3) are the first tigliane-type diterpenoid glucosides. Their structures were determined by a combination of 1D and 2D NMR, MS, and acid hydrolysis. Inhibitory activity against HIV-1 was assessed for compounds 1-5. The new compound 3 showed an EC₅₀ value of 0.02 μM and a therapeutic index (TI) of 17.50, while… CONTINUE READING

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