Tigliane diterpenes from the latex of Euphorbia obtusifolia with inhibitory activity on the mammalian mitochondrial respiratory chain.

@article{BetancurGalvis2003TiglianeDF,
  title={Tigliane diterpenes from the latex of Euphorbia obtusifolia with inhibitory activity on the mammalian mitochondrial respiratory chain.},
  author={Liliana A. Betancur-Galvis and Emilio Palomares and Juan Alberto Marco and Ernesto Estornell},
  journal={Journal of ethnopharmacology},
  year={2003},
  volume={85 2-3},
  pages={279-82}
}
Six diterpenes isolated from the latex of Euphorbia obtusifolia Poir. (Euphorbiaceae) were evaluated for their inhibition of the NADH oxidase activity in submitochondrial particles from beef heart. 4,20-Dideoxyphorbol-12,13-bis(isobutyrate) was the most potent inhibitor and showed an inhibitory concentration with IC(50) value of 2.6+/-0.3mM. In the present… CONTINUE READING