Tigliane Diterpenoids as a New Type of Antiadipogenic Agents Inhibit GRα-Dexras1 Axis in Adipocytes.

@article{Song2019TiglianeDA,
  title={Tigliane Diterpenoids as a New Type of Antiadipogenic Agents Inhibit GR$\alpha$-Dexras1 Axis in Adipocytes.},
  author={Qin-Qin Song and Yong Rao and Gui-Hua Tang and Zhang-Hua Sun and Junsheng Zhang and Zhishu Huang and Sheng Yin},
  journal={Journal of medicinal chemistry},
  year={2019},
  volume={62 4},
  pages={
          2060-2075
        }
}
The phytochemical study of Euphorbia prolifera led to the isolation of two tiglianes (1 and 2) and 23 mysrinanes (3-25). Most of these isolates showed significant antiadipogenic activity in 3T3-L1 adipocyte without apparent cytotoxicity. Subsequent structural modification yielded 10 derivatives, among which 1a, the 5- O-acetyl derivative of 1, turned out to be the most active compound with improved triglyceride-lowering activity (EC50 for 1 and 1a: 0.61 and 0.32 μM, respectively) and reduced… 
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