Tightly regulated, developmentally specific expression of the first open reading frame from LINE-1 during mouse embryogenesis.

@article{Trelogan1995TightlyRD,
  title={Tightly regulated, developmentally specific expression of the first open reading frame from LINE-1 during mouse embryogenesis.},
  author={S A Trelogan and Sandra L Martin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92 5},
  pages={1520-4}
}
LINE-1 (L1) has achieved its status as a middle repetitive DNA family in mammalian genomes by duplicative transposition. Although transposition may occur in any cell type, expression and transposition of a full-length functional element in the germ line are necessary for evolutionarily significant propagation of L1. An immunohistochemical analysis of adult mouse ovaries and mouse postimplantation embryos revealed expression of L1 open reading frame 1 in the germ line as well as in steroidogenic… CONTINUE READING

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