Tightly coupled repetitive blast-induced traumatic brain injury: development and characterization in mice.

@article{Wang2011TightlyCR,
  title={Tightly coupled repetitive blast-induced traumatic brain injury: development and characterization in mice.},
  author={Ying Wang and Yanling Wei and Samuel A. Oguntayo and William Wilkins and P. Bharath Arun and Manojkumar Valiyaveettil and Jian Song and Joseph B. Long and Madhusoodana P. Nambiar},
  journal={Journal of neurotrauma},
  year={2011},
  volume={28 10},
  pages={2171-83}
}
A mouse model of repeated blast exposure was developed using a compressed air-driven shock tube, to study the increase in severity of traumatic brain injury (bTBI) after multiple blast exposures. Isoflurane anesthetized C57BL/6J mice were exposed to 13.9, 20.6, and 25 psi single blast overpressure (BOP1) and allowed to recover for 5 days. BOP1 at 20.6 psi showed a mortality rate of 2% and this pressure was used for three repeated blast exposures (BOP3) with 1 and 30 min intervals. Overall… CONTINUE READING
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