Tightly clustered 11q23 and 22q11 breakpoints permit PCR-based detection of the recurrent constitutional t(11;22).

@article{Kurahashi2000TightlyC1,
  title={Tightly clustered 11q23 and 22q11 breakpoints permit PCR-based detection of the recurrent constitutional t(11;22).},
  author={Hiroki Kurahashi and Tamim H. Shaikh and E H Zackai and Livija Celle and Deborah Anne Driscoll and Marcia L. Budarf and Beverly S Emanuel},
  journal={American journal of human genetics},
  year={2000},
  volume={67 3},
  pages={763-8}
}
Palindromic AT-rich repeats (PATRRs) on chromosomes 11q23 and 22q11 at the constitutional t(11;22) breakpoint are predicted to induce genomic instability, which mediates the translocation. A PCR-based translocation-detection system for the t(11;22) has been developed with PCR primers flanking the PATRRs of both chromosomes, to examine the involvement of the PATRRs in the recurrent rearrangement. Forty unrelated carriers of the t(11;22) balanced translocation, plus two additional, independent… CONTINUE READING

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