Tight junctions on the move: molecular mechanisms for epithelial barrier regulation.

@article{Shen2012TightJO,
  title={Tight junctions on the move: molecular mechanisms for epithelial barrier regulation.},
  author={Le Shen},
  journal={Annals of the New York Academy of Sciences},
  year={2012},
  volume={1258},
  pages={9-18}
}
Increasing evidence suggests that the tight junction is a dynamically regulated structure. Cytoskeletal reorganization, particularly myosin light chain phosphorylation--induced actomyosin contraction, has increasingly been recognized as a mediator of physiological and pathophysiological tight junction regulation. However, our understanding of molecular mechanisms of tight junction modulation remains limited. Recent studies using live cell and live animal imaging techniques allowed us to peek… CONTINUE READING
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