Tight junctions, from tight intercellular seals to sophisticated protein complexes involved in drug delivery, pathogens interaction and cell proliferation.

@article{GonzlezMariscal2005TightJF,
  title={Tight junctions, from tight intercellular seals to sophisticated protein complexes involved in drug delivery, pathogens interaction and cell proliferation.},
  author={Lorenza Gonz{\'a}lez-Mariscal and Porfirio Nava},
  journal={Advanced drug delivery reviews},
  year={2005},
  volume={57 6},
  pages={811-4}
}
Tight junctions (TJ) are intercellular seals that regulate the passage of ions and molecules through the paracellular pathway. This property allows epithelial and endothelial sheets to function as barriers between different body compartments. Although TJ were identified by electron microscopy since the 1950's, the analysis in recent years of their molecular composition, has depicted TJ as signaling complexes involved in a wide spectrum of physiological and pathological processes, such as cell… CONTINUE READING