Tight junction proteins claudin-1 and occludin control hepatitis C virus entry and are downregulated during infection to prevent superinfection.

@article{Liu2009TightJP,
  title={Tight junction proteins claudin-1 and occludin control hepatitis C virus entry and are downregulated during infection to prevent superinfection.},
  author={Shufeng Liu and Wei Yang and Le Shen and Jerrold R Turner and Carolyn B Coyne and Tianyi Wang},
  journal={Journal of virology},
  year={2009},
  volume={83 4},
  pages={2011-4}
}
A tight junction (TJ) protein, claudin-1 (CLDN1), was identified recently as a key factor for hepatitis C virus (HCV) entry. Here, we show that another TJ protein, occludin, is also required for HCV entry. Mutational study of CLDN1 revealed that its tight junctional distribution plays an important role in mediating viral entry. Together, these data support the model in which HCV enters liver cells from the TJ. Interestingly, HCV infection of Huh-7 hepatoma cells downregulated the expression of… CONTINUE READING