Tight control of transgene expression by lentivirus vectors containing second-generation tetracycline-responsive promoters.

@article{Pluta2005TightCO,
  title={Tight control of transgene expression by lentivirus vectors containing second-generation tetracycline-responsive promoters.},
  author={Krzysztof Pluta and Milson J Luce and Lili Bao and Siamak Agha-Mohammadi and Jakob Reiser},
  journal={The journal of gene medicine},
  year={2005},
  volume={7 6},
  pages={803-17}
}
BACKGROUND The goal of this study was to design improved regulatable lentivirus vector systems. The aim was to design tetracycline (tet)-regulatable lentivirus vectors based on the Tet-on system displaying low background expression in the absence of the doxycycline (DOX) inducer and high transgene expression levels in the presence of DOX. METHODS We constructed a binary lentivirus vector system that is composed of a self-inactivating (SIN) lentivirus vector bearing inducible first- or second… CONTINUE READING

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