Tight control of gene expression by a helper-dependent adenovirus vector carrying the rtTA2s-M2 tetracycline transactivator and repressor system

@article{Salucci2002TightCO,
  title={Tight control of gene expression by a helper-dependent adenovirus vector carrying the rtTA2s-M2 tetracycline transactivator and repressor system},
  author={V. Salucci and A. Scarito and L. Aurisicchio and S. Lamartina and G. Nicolaus and S. Giampaoli and O. Gonzalez-Paz and C. Toniatti and H. Bujard and W. Hillen and G. Ciliberto and F. Palombo},
  journal={Gene Therapy},
  year={2002},
  volume={9},
  pages={1415-1421}
}
  • V. Salucci, A. Scarito, +9 authors F. Palombo
  • Published 2002
  • Biology, Medicine
  • Gene Therapy
  • Control of gene expression for gene therapy application requires the design of a sophisticated system embodying multiple properties. The ideal system should present the following features: (1) low or undetectable gene expression in the absence of inducer; (2) strong expression upon induction; and (3) fast kinetics of induction in the presence of inducers and rapid reversal of induction after its withdrawal. To evaluate these parameters, the features of the latest generation tetracycline… CONTINUE READING
    Stringent doxycycline-dependent control of gene activities using an episomal one-vector system
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