Tight control and intensified COBRA combination treatment in early rheumatoid arthritis: 90% remission in a pilot trial.

@article{Tuyl2008TightCA,
  title={Tight control and intensified COBRA combination treatment in early rheumatoid arthritis: 90% remission in a pilot trial.},
  author={Lilian H D van Tuyl and Willem Frederik Lems and Alexandre E. Voskuyl and Pit J. S. M. Kerstens and Patrick Garnero and Ben A. C. Dijkmans and Maarten Boers},
  journal={Annals of the rheumatic diseases},
  year={2008},
  volume={67 11},
  pages={1574-7}
}
OBJECTIVE To investigate the efficacy and feasibility of an intensive combination treatment in early rheumatoid arthritis (RA) combined with monitoring both disease activity and cartilage degradation. METHODS In a pilot trial, 21 patients with active early RA (mean DAS28 5.3; mean disease duration 3 months) were treated with COBRA treatment comprising sulfasalazine, methotrexate and high-dose step-down prednisolone, intensified by adding hydroxychloroquine and continued low-dose prednisolone… CONTINUE READING