Tight binding inhibitors of N-acyl amino sugar and N-acyl amino acid deacetylases.

Abstract

Very potent inhibitors were synthesized for the enzymatic deacetylation of N-acetyl-d-glucosamine-6-phosphate (NagA) and N-acetyl-d-glutamate (DGD). The methyl phosphonamidate derivative of d-glucosamine-6-phosphate bound to N-acetyl-d-glucosamine-6-phosphate deacetylase with an equilibrium dissociation constant of 34 +/- 5 nM at pH 7.5 and an association… (More)

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@article{Xu2006TightBI, title={Tight binding inhibitors of N-acyl amino sugar and N-acyl amino acid deacetylases.}, author={Chengfu Xu and Richard S. Hall and Jennifer A Cummings and Frank M Raushel}, journal={Journal of the American Chemical Society}, year={2006}, volume={128 13}, pages={4244-5} }