Tight Junction Regulation by Morphine and HIV-1 Tat Modulates Blood–Brain Barrier Permeability

@article{Mahajan2008TightJR,
  title={Tight Junction Regulation by Morphine and HIV-1 Tat Modulates Blood–Brain Barrier Permeability},
  author={Supriya D. Mahajan and Ravikumar Aalinkeel and Donald E. Sykes and Jessica L. Reynolds and B. Bindukumar and Stanley F. Fernandez and Ramnik Chawda and Thomas C. Shanahan and Stanley A. Schwartz},
  journal={Journal of Clinical Immunology},
  year={2008},
  volume={28},
  pages={528-541}
}
Human immunodeficiency virus (HIV)-1 patients who abuse opiates are at a greater risk of developing neurological complications of AIDS. Alterations in blood–brain barrier (BBB) integrity are associated with cytoskeletal disorganization and disruption of tight junction (TJ) integrity. We hypothesize that opiates in combination with HIV-1 viral proteins can modulate TJ expression in primary brain microvascular endothelial cells (BMVEC), thereby compromising BBB integrity and exacerbating HIV-1… CONTINUE READING
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