Tight Junction–associated MARVEL Proteins MarvelD3, Tricellulin, and Occludin Have Distinct but Overlapping Functions

@inproceedings{Raleigh2010TightJM,
  title={Tight Junction–associated MARVEL Proteins MarvelD3, Tricellulin, and Occludin Have Distinct but Overlapping Functions},
  author={David R. Raleigh and Amanda M. Marchiando and Yong E. Zhang and Le Shen and Hiroyuki Sasaki and Yingmin Wang and Manyuan Long and Jerrold R Turner},
  booktitle={Molecular biology of the cell},
  year={2010}
}
In vitro studies have demonstrated that occludin and tricellulin are important for tight junction barrier function, but in vivo data suggest that loss of these proteins can be overcome. The presence of a heretofore unknown, yet related, protein could explain these observations. Here, we report marvelD3, a novel tight junction protein that, like occludin and tricellulin, contains a conserved four-transmembrane MARVEL (MAL and related proteins for vesicle trafficking and membrane link) domain… CONTINUE READING

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