Tight Glycemic Control With Insulin in Hyperglycemic Preterm Babies: A Randomized Controlled Trial

  title={Tight Glycemic Control With Insulin in Hyperglycemic Preterm Babies: A Randomized Controlled Trial},
  author={William E. Benitz},
Gender and glycaemia: Insulin sensitivity and secretion in premature neonates
C-peptide concentrations are used to more accurately analyse insulin secretion in a VLBW neonatal cohort, and a comparison of insulin secretion and sensitivity is made between male and female sub cohorts.
Performance and Safety of STAR Glycaemic Control in Neonatal Intensive Care: Further Clinical Results Including Pilot Results from a New Protocol Implementation
STAR (Stochastic TARgeted) is a model-based glycaemic framework that mitigates the risks of hypoglycaemia through quantification of current insulin sensitivity and future variability in neonates treated with STAR in the NICU.
The potential risks and benefits of insulin treatment in hyperglycaemic preterm neonates.
  • C. Morgan
  • Medicine, Biology
    Early human development
  • 2015
Assessing the benefits and risks of tight glycemic control in critically ill children
This work is distributed under the terms of the License http://creativecommons.org/licenses/by-nc/3.0/.
Glucose Derangements and Brain Function in Neonatal Encephalopathy
The hypothesis that proactive avoidance of hyperglycemia may be a neuroprotective strategy in infants with neonatal encephalopathy is supported.
Factors affecting glucose homeostasis in premature neonates
This thesis aims to investigate the role ofglucose homeostasis in the preterm neonate in the context ofhyperglycaemia and pharmacokinetic studies in paediatrics and neonates and its applications in neonates.
A C-Peptide-Based Model of Pancreatic Insulin Secretion in Extremely Preterm Neonates in Intensive Care
A sex-based insulin secretion model was created and incorporated into a model-based glycemic control framework and found to be highly variable between patients and over time, and could not be modeled with respect to age, weight, or protein or dextrose intake.
Effects of Preterm Birth and Neonatal Hyperglycaemia on the Developing Pancreas and Liver
It is suggested that preterm birth itself may result in significantly reduced β cell mass in adulthood and mechanisms which may underlie these findings are indicated.
ESPGHAN / ESPEN / ESPR guidelines on pediatric parenteral nutrition : Carbohydrates
ESPGHAN/ESPEN/ESPR guidelines on pediatric parenteral nutrition: Carbohydrates D. Mesotten a, , K. Joosten , A. van Kempen , S. Verbruggen , the ESPGHAN/ESPEN/ ESPR/CSPEN working group on pediatric
Relationships Between Early Nutrition and Blood Glucose Concentrations in Very Preterm Infants
In very preterm infants, macronutrient balance and small, early enteral feeds may assist glycemic control, as well as changes to early nutrition, before and after a change in nutritional protocol.


Early insulin therapy in very-low-birth-weight infants.
Early insulin therapy offers little clinical benefit in very-low-birth-weight infants, and reduces hyperglycemia but may increase hypoglycemia in infants with birth weights of more than 1 kg.
Tight Glycemic Control With Insulin in Hyperglycemic Preterm Babies: A Randomized Controlled Trial
Tight glycemic control with insulin in hyperglycemic preterm infants increases weight gain and head growth, but at the expense of reduced linear growth and increased risk of hypoglycemia.