Tight Coupling Between Electrical Activity and Exocytosis in Mouse Glucagon-Secreting-Cells

  title={Tight Coupling Between Electrical Activity and Exocytosis in Mouse Glucagon-Secreting-Cells},
  author={Sebastian Barg and Juris Galvanovskis and Sven O. G{\"o}pel and Patrik Rorsman and Lena Eliasson},
-Cells were identified in preparations of dispersed mouse islets by immunofluorescence microscopy. A high fraction of -cells correlated with a small cell size measured as the average cell diameter (10 μm) and whole-cell capacitance (<4 pF). The -cells generated action potentials at a low frequency (1 Hz) in the absence of glucose. These action potentials were reversibly inhibited by elevation of the glucose concentration to 20 mmol/l. The action potentials originated from a membrane potential… CONTINUE READING
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Glucagon - like peptide I and glucose - dependent insulinotropic polypeptide stimulate Ca 2 + - induced secretion in rat  - cells by a protein kinase A – mediated mechanism

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