Tight Coupling Between Electrical Activity and Exocytosis in Mouse Glucagon-Secreting-Cells

@inproceedings{Barg2000TightCB,
  title={Tight Coupling Between Electrical Activity and Exocytosis in Mouse Glucagon-Secreting-Cells},
  author={Sebastian Barg and Juris Galvanovskis and Sven O. G{\"o}pel and Patrik Rorsman and Lena Eliasson},
  year={2000}
}
-Cells were identified in preparations of dispersed mouse islets by immunofluorescence microscopy. A high fraction of -cells correlated with a small cell size measured as the average cell diameter (10 μm) and whole-cell capacitance (<4 pF). The -cells generated action potentials at a low frequency (1 Hz) in the absence of glucose. These action potentials were reversibly inhibited by elevation of the glucose concentration to 20 mmol/l. The action potentials originated from a membrane potential… CONTINUE READING
30 Citations
35 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 30 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 35 references

Glucagon - like peptide I and glucose - dependent insulinotropic polypeptide stimulate Ca 2 + - induced secretion in rat  - cells by a protein kinase A – mediated mechanism

  • J Gromada, K Bokvist, +4 authors R Rorsman
  • Diabetes
  • 1997

Similar Papers

Loading similar papers…