Tight, cell type-specific control of LNX expression in the nervous system, at the level of transcription, translation and protein stability.

@article{Lenihan2014TightCT,
  title={Tight, cell type-specific control of LNX expression in the nervous system, at the level of transcription, translation and protein stability.},
  author={Joan A. Lenihan and Orthis Saha and Louise M Mansfield and Paul W Young},
  journal={Gene},
  year={2014},
  volume={552 1},
  pages={39-50}
}
LNX1 and LNX2 are E3 ubiquitin ligases that can interact with Numb - a key regulator of neurogenesis and neuronal differentiation. LNX1 can target Numb for proteasomal degradation, and Lnx mRNAs are prominently expressed in the nervous system, suggesting that LNX proteins play a role in neural development. This hypothesis remains unproven, however, largely… CONTINUE READING