Tigecycline exhibits inhibitory activity against Clostridium difficile in the colon of mice and does not promote growth or toxin production.

@article{Jump2011TigecyclineEI,
  title={Tigecycline exhibits inhibitory activity against Clostridium difficile in the colon of mice and does not promote growth or toxin production.},
  author={Robin L P Jump and Yuejin Li and Michael J. Pultz and Georgios Kypriotakis and Curtis J. Donskey},
  journal={Antimicrobial agents and chemotherapy},
  year={2011},
  volume={55 2},
  pages={546-9}
}
Tigecycline is a broad-spectrum glycylcycline antibiotic with potent in vitro activity against Clostridium difficile. We used a mouse model to test the hypothesis that tigecycline has a low propensity to promote colonization and toxin production by C. difficile due to inhibitory activity in the colon. Mice (5 to 8 per group) received subcutaneous injections of tigecycline (low and high doses) alone or in combination with clindamycin for 6 days. Growth of and toxin production by 3 strains of C… CONTINUE READING