Tigecycline activity: low resistance rates but problematic disc breakpoints revealed by a multicentre sentinel survey in the UK.

  title={Tigecycline activity: low resistance rates but problematic disc breakpoints revealed by a multicentre sentinel survey in the UK.},
  author={Russell Hope and Shazad Mushtaq and Dorothy James and Teresa Pllana and Marina Warner and David M Livermore},
  journal={The Journal of antimicrobial chemotherapy},
  volume={65 12},
OBJECTIVES A multicentre surveillance of tigecycline activity against relevant pathogens in the UK. METHODS Forty-three representative UK hospitals were each asked to test 150 consecutive, clinically significant isolates from hospitalized patients, excluding those from urine or faeces. The sentinel laboratories tested all these isolates against a panel of antibiotics by the BSAC disc method and a selection of isolates were retested centrally by the BSAC agar dilution method. RESULTS The… 

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