Tiered application of the neutral red release and EpiOcular™ assays for evaluating the eye irritation potential of agrochemical formulations.

@article{Settivari2016TieredAO,
  title={Tiered application of the neutral red release and EpiOcular™ assays for evaluating the eye irritation potential of agrochemical formulations.},
  author={Raja S Settivari and Ricardo Acosta Amado and Marco Corvaro and Nicolo R Visconti and Lynn H L Kan and Edward W. Carney and D. R. Boverhof and Sean C Gehen},
  journal={Regulatory toxicology and pharmacology : RTP},
  year={2016},
  volume={81},
  pages={407-420}
}
Agrochemical formulations have been underrepresented in validation efforts for implementing alternative eye irritation approaches but represent a significant opportunity to reduce animal testing. This study assesses the utility of the neutral red release assay (NRR) and EpiOcular™ assay (EO) for predicting the eye irritation potential of 64 agrochemical formulations relative to Draize data. In the NRR, formulations with an NRR50 value ≤ 50 mg/mL were categorized as UN GHS Cat 1 and those >250… CONTINUE READING
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