Tiered analytics for purity assessment of macrocyclic peptides in drug discovery: Analytical consideration and method development.

Abstract

Synthetic macrocyclic peptides with natural and unnatural amino acids have gained considerable attention from a number of pharmaceutical/biopharmaceutical companies in recent years as a promising approach to drug discovery, particularly for targets involving protein-protein or protein-peptide interactions. Analytical scientists charged with characterizing… (More)
DOI: 10.1016/j.jpba.2017.01.056

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