Tied up in loops: positive and negative autoregulation of p53.

@article{Lu2010TiedUI,
  title={Tied up in loops: positive and negative autoregulation of p53.},
  author={Xin Lu},
  journal={Cold Spring Harbor perspectives in biology},
  year={2010},
  volume={2 5},
  pages={a000984}
}
The tumor suppressor p53 is a master sensor of stress that controls many biological functions, including implantation, cell-fate decisions, metabolism, and aging. In response to a defined stress signal such as gamma radiation, the response of p53 is heterogeneous in vivo. Like a complex barcode, the ability of p53 to function as a central hub that integrates defined stress signals into decisive cellular responses, in a time- and cell-type dependent manner, is facilitated by the extraordinary… CONTINUE READING